Zebrafish Bacterial Infection Assay to Study Host-Pathogen Interactions
نویسندگان
چکیده
منابع مشابه
Host-Pathogen Interactions Made Transparent with the Zebrafish Model
The zebrafish holds much promise as a high-throughput drug screening model for immune-related diseases, including inflammatory and infectious diseases and cancer. This is due to the excellent possibilities for in vivo imaging in combination with advanced tools for genomic and large scale mutant analysis. The context of the embryo's developing immune system makes it possible to study the contrib...
متن کاملA Sensitive High-Throughput Assay for Evaluating Host-Pathogen Interactions in Cryptococcus neoformans Infection
BACKGROUND Cryptococcus neoformans causes serious disease in immunocompromised individuals, leading to over 600,000 deaths per year worldwide. Part of this impact is due to the organism's ability to thwart what should be the mammalian hosts' first line of defense against cryptococcal infection: internalization by macrophages. Even when C. neoformans is engulfed by host phagocytes, it can surviv...
متن کاملForeign Body Infection Models to Study Host-Pathogen Response and Antimicrobial Tolerance of Bacterial Biofilm.
The number of implanted medical devices is steadily increasing and has become an effective intervention improving life quality, but still carries the risk of infection. These infections are mainly caused by biofilm-forming staphylococci that are difficult to treat due to the decreased susceptibility to both antibiotics and host defense mechanisms. To understand the particular pathogenesis and t...
متن کاملBacterial Lipoproteins Diverse Role in Host-Pathogen Interactions
Introduction In the recent years, primarily due to the advances in genome sequencing of bacteria, an increased number of lipoproteins have been predicted in the various strains of bacteria. Bacterial lipoproteins are critical for the survival of both the Grampositive and Gram-negative bacteria. Bacteria are found on the surface of host or within the body as commensals or as pathogenic organisms...
متن کاملBacterial endophthalmitis: therapeutic challenges and host-pathogen interactions.
Endophthalmitis is an infection of the posterior segment of the eye that frequently results in loss of vision. This devastating result occurs despite prompt and often aggressive therapeutic and surgical intervention. Over the past decade, research has centered on determining the bacterial and host factors involved in this potentially blinding disease. The initial focus on the bacterial factors ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BIO-PROTOCOL
سال: 2020
ISSN: 2331-8325
DOI: 10.21769/bioprotoc.3536